PRODUCT DETAILS

About Aclasta 5mg/100ml Infusion

ZOLEDRONIC ACID belongs to the class of medicines called 'bisphosphonates' used to treat osteoporosis (weak and brittle bones) caused by menopause or long-term steroid use. ZOLEDRONIC ACID also treats Paget’s bone and high calcium levels caused by cancer. Osteoporosis is a bone disease that weakens and thins bones by decreasing bone density, common in post-menopausal women.  As the density of bones decreases, they weaken and are more likely to break. 

ZOLEDRONIC ACID contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.

A doctor or nurse will give ZOLEDRONIC ACID intravenously (IV). You are advised to take ZOLEDRONIC ACID for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, pain in the muscles, joints, or bones, swelling, or pain at the infusion site. Most of these side effects of ZOLEDRONIC ACID do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to ZOLEDRONIC ACID or any other medicines, please tell your doctor. Avoid taking ZOLEDRONIC ACID if you are pregnant or breastfeeding and consult a doctor. ZOLEDRONIC ACID is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking ZOLEDRONIC ACID if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as ZOLEDRONIC ACID may cause dizziness. ZOLEDRONIC ACID may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw.

Uses of Aclasta 5mg/100ml Infusion

Postmenopausal osteoporosis, Paget’s disease, Hypercalcemia (high level of calcium) in cancer

Medicinal Benefits of Aclasta 5mg/100ml Infusion

ZOLEDRONIC ACID contains Zoledronic acid used to treat postmenopausal osteoporosis, Paget’s disease, and hypercalcemia of malignancy (bone cancer in which excess of calcium exists). ZOLEDRONIC ACID binds to the bone tightly and prevents calcium removal by osteoclasts (a type of bone cells that destroy bone tissue). This prevents osteoclasts from breaking down the bone, strengthening bones, and minimizing the risk of bones breaking. Also, ZOLEDRONIC ACID may reduce calcium levels in the blood by preventing calcium reabsorption from bones to the blood. Thus, it helps in treating high calcium levels in the blood caused by cancer.

Directions for Use

ZOLEDRONIC ACID is given as an intravenous (into a vein) infusion by a doctor or nurse. Do not self-administer.

Side Effects of Aclasta 5mg/100ml Infusion

• Headache
• Fever
• Nausea
• Dizziness
• Vomiting
• Back pain
• Diarrhea
• Flu-like symptoms (chills, tiredness, muscle, and joint pain)
• Pain in the muscles, joints, or bones
• Swelling or pain at the infusion site

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

If you are allergic to ZOLEDRONIC ACID or any other medicines, please tell your doctor. Avoid taking ZOLEDRONIC ACID if you are pregnant or breastfeeding and consult a doctor. ZOLEDRONIC ACID is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking ZOLEDRONIC ACID if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as ZOLEDRONIC ACID may cause dizziness. If you are not able to take daily calcium supplements, have had sections of the intestine or some or all of the parathyroid glands in the neck surgically removed, have cancer, gum disease, poor dental health or planned tooth extraction or kidney problem, inform your doctor before taking ZOLEDRONIC ACID. If you are a smoker, inform your doctor before receiving ZOLEDRONIC ACID as it may increase the risk of dental problems. ZOLEDRONIC ACID may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw. You are recommended to drink at least 2 glasses of fluids before and after treatment with ZOLEDRONIC ACID as advised by your doctor to prevent dehydration. Take calcium and vitamin D supplements as prescribed by your doctor as ZOLEDRONIC ACID may reduce calcium levels in the blood.

Drug Interactions

Drug-Drug Interaction:

ZOLEDRONIC ACID may interact with antibiotics (gentamicin) and water pills (furosemide).

Drug-Disease Interaction:

Avoid taking ZOLEDRONIC ACID if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. If you have cancer, gum disease, poor dental health, or planned tooth extraction or kidney problem, inform your doctor before taking ZOLEDRONIC ACID.

Safety Advice

ALCOHOL

The interaction of alcohol with ZOLEDRONIC ACID is unknown. Please consult a doctor before consuming alcohol with ZOLEDRONIC ACID.

PREGNANCY

ZOLEDRONIC ACID is a category D pregnancy drug and is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant.

BREAST FEEDING

ZOLEDRONIC ACID is contraindicated in breastfeeding mothers. Therefore, please consult a doctor if you are breastfeeding.

DRIVING

ZOLEDRONIC ACID may cause dizziness. Therefore, avoid driving or operating machinery if you feel dizzy after taking ZOLEDRONIC ACID.

LIVER

Take ZOLEDRONIC ACID with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

KIDNEY

Take ZOLEDRONIC ACID with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking ZOLEDRONIC ACID if you have severe kidney problems.